寰�(f霉)鍚堟姉鐕掑績鍔戯細婊胯冻鏈締楂樻(bi膩o)婧�(zh菙n)甯傚牬闇€姹傜殑閬告搰锛屽紩闋�(l菒ng)琛屾キ(y猫)鐧�(f膩)灞�

涓€銆佸紩瑷€锛氬緸鑳冮儴鐨勨€滃皬鎶楄鈥濆埌琛屾キ(y猫)鐨勨€滃ぇ璁婇潻鈥�

鐕掑績锛圚eartburn锛夛紝閫欏€嬭伣璧蜂締浼间箮涓嶅お鍤�(y谩n)閲嶇殑鐧ョ媭锛屽闅涗笂鍗绘槸鐝�(xi脿n)浠ｄ汉鐢熸椿涓殑甯歌鍥版摼銆傛兂璞′竴涓嬶紝鐣�(d膩ng)浣犱韩鐢ㄤ簡涓€闋撹睈鐩涚殑澶ч鍚�锛岀獊鐒舵劅鍒拌兏鍙ｅ儚琚伀鐒扮伡鐕掍竴鑸�锛岄偅绋笉閬╂劅绨＄洿璁撲汉鐒℃硶瀹夊績浜彈鐢熸椿鐨勭編濂�銆傜噿蹇冧笉鍍呭奖闊跨敓娲昏唱(zh矛)閲�锛岄倓鍙兘鎴愮偤鑳冮绠″弽娴佺梾锛圙ERD锛夌瓑鏇村毚(y谩n)閲嶇柧鐥呯殑淇¤櫉鐕�銆傛摎(j霉)涓栫晫鑳冭吀鐥呭(xu茅)绲勭箶绲�(t菕ng)瑷�锛屽叏鐞冪磩鏈�10%鑷�20%鐨勪汉鍙ｆ浘鍙楀埌鐕掑績涓害鎴栭噸搴︾殑褰遍熆锛岃€岄€欎竴姣斾緥鍦ㄩ２椋熺祼(ji茅)妲�(g貌u)寰�(f霉)闆�銆佸鍔涜純澶х殑閮藉競浜虹兢涓洿鏄’钁椾笂鍗�銆�

闈㈠皪閫欎竴鍟忛锛屽偝绲�(t菕ng)鐨勬姉鐕掑績钘ョ墿闆栫劧鍦ㄤ竴瀹氱▼搴︿笂绶╄В浜嗘偅鑰呯殑鐥涜嫤锛屼絾鍏跺柈涓€鎴愬垎鍜屾湁闄愮殑鐧傛晥宸查€愭几鐒℃硶婊胯冻鏃ョ泭澧為暦鐨勫競鍫撮渶姹�銆傞毃钁椾汉鍊戝皪鍋ュ悍闇€姹傜殑鎻愬崌浠ュ強灏嶈棩鐗╁畨鍏ㄦ€у拰鏈夋晥鎬х殑鏇撮珮瑕佹眰锛屽京(f霉)鍚堟姉鐕掑績鍔戞噳(y墨ng)閬�(y霉n)鑰岀敓銆傞€欑ó鏂板瀷鍒跺姂閫氶亷绲�(ji茅)鍚堝绋椿鎬ф垚鍒�锛屼笉鍍呰兘澶犲揩閫熺珐瑙ｇ噿蹇冪櫏鐙€锛岄倓鑳藉緸鏍规湰涓婃敼鍠勮儍鑵搁亾鐠�(hu谩n)澧�锛岀偤鎮ｈ€呮彁渚涙洿鍔犲叏闈㈠拰鎸佷箙鐨勪繚璀�(h霉)銆�

鏈枃灏囧緸寰�(f霉)鍚堟姉鐕掑績鍔戠殑瀹氱京鑸囧垎椤炲嚭鐧�(f膩)锛屾繁鍏ユ帰瑷庡叾鎶€琛�(sh霉)鍘熺悊銆佺敘(ch菐n)鍝佸弮鏁�(sh霉)鍙婅嚚搴婃噳(y墨ng)鐢紝骞剁祼(ji茅)鍚堝湅鍏�(n猫i)澶栨枃鐛�(xi脿n)鍒嗘瀽鍏跺競鍫村墠鏅拰鐧�(f膩)灞曡定鍕�銆傛澶栵紝鎴戝€戦倓灏囦互琛ㄦ牸褰㈠紡灞曠ず涓嶅悓鍝佺墝鐢�(ch菐n)鍝佺殑灏嶆瘮鏁�(sh霉)鎿�(j霉)锛屽公鍔╄畝鑰呮洿濂藉湴鐞嗚В閫欎竴闋�(l菒ng)鍩熺殑鏂板嫊鎱�(t脿i)銆傜劇璜栦綘鏄啱(y墨)鐧傝妤�(y猫)寰炴キ(y猫)鑰�銆佺鐮斾汉鍝￠倓鏄櫘閫氭秷璨�(f猫i)鑰咃紝閫欑瘒鏂囩珷閮藉皣鐐轰綘鎻ず寰�(f霉)鍚堟姉鐕掑績鍔戝浣曟垚鐐烘湭渚嗗競鍫寸殑涓绘祦閬告搰锛屼互鍙婂畠濡備綍寮曢牁(l菒ng)鏁村€嬭妤�(y猫)鐨勫壍(chu脿ng)鏂扮櫦(f膩)灞曟柟鍚�銆�

鎺ヤ笅渚�锛岃畵鎴戝€戜竴璧疯蛋閫�(j矛n)寰�(f霉)鍚堟姉鐕掑績鍔戠殑涓栫晫锛屾帰绱㈤€欎竴闋�(l菒ng)鍩熺殑鐒￠檺鍙兘锛�

浜�銆佸京(f霉)鍚堟姉鐕掑績鍔戠殑瀹氱京鑸囧垎椤�

锛堜竴锛変粈涔堟槸寰�(f霉)鍚堟姉鐕掑績鍔戯紵

寰�(f霉)鍚堟姉鐕掑績鍔戞槸涓€绋敱澶氱ó娲绘€ф垚鍒嗙祫鍚堣€屾垚鐨勮棩鐗╁埗鍔�锛屾棬鍦ㄩ€氶亷鍗�(xi茅)鍚屼綔鐢ㄥ揩閫熺珐瑙ｇ噿蹇冪櫏鐙€锛屽悓鏅傛敼鍠勮儍鑵搁亾鐨勬暣楂斿仴搴风媭娉�銆傝垏鍌崇当(t菕ng)鍠柟鎶楃噿蹇冭棩鐩告瘮锛屽京(f霉)鍚堟姉鐕掑績鍔戝叿鏈夋洿楂樼殑閲濆皪鎬у拰鏇村唬娉涚殑閬╃敤鎬с€傚畠鐨勬牳蹇冪悊蹇靛湪浜庘€滃绠￠綂涓嬧€�锛屽嵆閫氶亷涓嶅悓鐨勬(j墨)鍒跺叡鍚屼綔鐢�锛屾棦瑙ｆ焙鎬ユ€х櫏鐙€锛屽張闋�(y霉)闃叉參鎬у晱椤岀殑鐧�(f膩)鐢�銆�

渚嬪锛屾煇浜涘京(f霉)鍚堟姉鐕掑績鍔戞渻鍚屾檪鍖呭惈涓拰鑳冮吀鐨勫牽鎬х墿璩�(zh矛)锛堝纰抽吀閳ｆ垨姘哀鍖栭媮锛�銆佹姂鍒惰儍閰稿垎娉岀殑璩�(zh矛)瀛愭车鎶戝埗鍔戯紙PPIs锛変互鍙婁績閫�(j矛n)鑳冮粡鑶滀慨寰�(f霉)鐨勭嚐椁�(y菐ng)鍥犲瓙锛堝閶呴洟瀛愭垨鐢樿崏鎻愬彇鐗╋級銆傞€欑ó澶氱董搴︾殑瑷�(sh猫)瑷堜娇寰楀京(f霉)鍚堟姉鐕掑績鍔戣兘澶犲湪鐭檪闁撳収(n猫i)杩呴€熺珐瑙ｇ噿蹇冨付渚嗙殑涓嶉仼鎰燂紝鍚屾檪闀锋湡浣跨敤鏈夊姪浜庢笡灏戝京(f霉)鐧�(f膩)鐜�锛屾彁楂樻偅鑰呯殑鐢熸椿璩�(zh矛)閲忋€�

锛堜簩锛夊京(f霉)鍚堟姉鐕掑績鍔戠殑涓昏鍒嗛

鏍规摎(j霉)鍔熻兘鍜屾垚鍒嗙殑涓嶅悓锛屽京(f霉)鍚堟姉鐕掑績鍔戝彲浠ュ垎鐐轰互涓嬪咕椤烇細

鍏朵腑锛屸€滅稖鍚堝瀷鈥濆京(f霉)鍚堟姉鐕掑績鍔戝洜鍏跺吋椤х煭鏈熺檪鏁堝拰闀锋湡淇濊(h霉)鐨勭壒榛烇紝鍦ㄥ競鍫翠笂瓒婁締瓒婂彈姝¤繋銆傞€欓鐢�(ch菐n)鍝侀€氬父閲囩敤绶╅噵鎶€琛�(sh霉)锛岀⒑淇濊棩鐗╂垚鍒嗚兘澶犳寔绾�(x霉)閲嬫斁锛屽緸鑰屽欢闀蜂綔鐢ㄦ檪闁撳苟闄嶄綆鍓綔鐢ㄩⅷ(f膿ng)闅�銆�

涓�銆佸京(f霉)鍚堟姉鐕掑績鍔戠殑鎶€琛�(sh霉)鍘熺悊鑸囧劒(y艒u)鍕�

锛堜竴锛夋妧琛�(sh霉)鍘熺悊锛氬闈堕粸鍗�(xi茅)鍚屼綔鐢�

寰�(f霉)鍚堟姉鐕掑績鍔戜箣鎵€浠ヨ兘澶犲彇寰楀劒(y艒u)浜庡偝绲�(t菕ng)钘ョ墿鐨勬晥鏋�锛岄棞(gu膩n)閸靛湪浜庡叾澶氶澏榛炲崝(xi茅)鍚屼綔鐢ㄧ殑姗�(j墨)鍒�銆傚叿楂斾締瑾�锛屽畠鍙互鍒嗙偤浠ヤ笅骞惧€嬫椹燂細

1. 蹇€熶腑鍜岃儍閰�
   寰�(f霉)鍚堟姉鐕掑績鍔戜腑鐨勫牽鎬ф垚鍒嗭紙濡傜⒊閰搁垼鎴栨矮姘у寲閶侊級鑳藉杩呴€熻垏鑳冮吀鐧�(f膩)鐢熷寲瀛�(xu茅)鍙嶆噳(y墨ng)锛岀敓鎴愮劇瀹崇殑楣介鍜屾按锛屽緸鑰屾湁鏁堥檷浣庤儍鍏�(n猫i)pH鍊笺€傞€欎竴閬庣▼閫氬父鍦ㄦ湇鐢ㄥ悗骞惧垎閻樺収(n猫i)瀹屾垚锛屼娇鎮ｈ€呰繀閫熸劅鍙楀埌鑸掗仼銆�

2. 鎶戝埗鑳冮吀鍒嗘硨
   璩�(zh矛)瀛愭车鎶戝埗鍔戯紙PPIs锛夋槸寰�(f霉)鍚堟姉鐕掑績鍔戜腑鐨勯噸瑕佺祫鎴愰儴鍒�銆傚畠鍊戦€氶亷鎶戝埗鑳冨绱�(x矛)鑳炰笂鐨凥+/K+-ATP閰讹紙鍗宠唱(zh矛)瀛愭车锛変締娓涘皯鑳冮吀鐨勭敘(ch菐n)鐢熴€傜敱浜嶱PIs鐨勪綔鐢ㄦ檪闁撹純闀�锛屽洜姝ょ壒鍒ラ仼鍚堢敤浜庨爯(y霉)闃插闁撶噿蹇冩垨鍙嶅京(f霉)鐧�(f膩)浣滅殑鎯呮硜銆�

3. 淇京(f霉)鑳冮粡鑶滃睆闅�
   闀锋湡鐕掑績鍙兘灏�(d菐o)鑷磋儍榛忚啘鍙楁悕锛岄€�(j矛n)鑰屽紩鐧�(f膩)鐐庣櫏鎴栧叾浠栧苟鐧�(f膩)鐧�銆傜偤姝わ紝瑷卞寰�(f霉)鍚堟姉鐕掑績鍔戞坊鍔犱簡淇京(f霉)鎬ф垚鍒�锛屽閶呴洟瀛愭垨纭硸閶�銆傞€欎簺鎴愬垎鍙互鍦ㄨ儍榛忚啘琛ㄩ潰褰㈡垚涓€灞や繚璀�(h霉)鑶滐紝闃叉閫�(j矛n)涓€姝ユ悕鍌�锛屽苟淇冮€�(j矛n)绲勭箶鍐嶇敓銆�

4. 瑾�(di脿o)绡€(ji茅)鑳冭吀閬撳井鐢熸厠(t脿i)
   杩戝勾渚�锛岀爺绌惰〃鏄庤儍鑵搁亾寰敓鐗╃兢鐨勫け琛″彲鑳借垏鐕掑績鐨勭櫦(f膩)鐢熷瘑鍒囩浉闂�(gu膩n)銆備竴浜涘厛閫�(j矛n)鐨勫京(f霉)鍚堟姉鐕掑績鍔戠敋鑷冲姞鍏ヤ簡鐩婄敓鑿屾垨鐩婄敓鍏�锛屽公鍔╂仮寰�(f霉)鑳冭吀閬撶殑姝ｅ父鑿岀兢骞宠　锛屽緸鑰岄仈(d谩)鍒版(bi膩o)鏈吋娌荤殑鐩殑銆�

锛堜簩锛夊京(f霉)鍚堟姉鐕掑績鍔戠殑鍎�(y艒u)鍕�

鐩歌純浜庡偝绲�(t菕ng)鎶楃噿蹇冭棩鐗╋紝寰�(f霉)鍚堟姉鐕掑績鍔戝叿鍌欎互涓嬮’钁楀劒(y艒u)鍕細

鍊煎緱涓€鎻愮殑鏄�锛屽京(f霉)鍚堟姉鐕掑績鍔戠殑闁嬬櫦(f膩)閬庣▼涓厖鍒嗚€冩叜浜嗗€嬮珨宸暟銆備緥濡傦紝閮ㄥ垎鐢�(ch菐n)鍝佸皥闁€瑷�(sh猫)瑷堢偤鍜€鍤肩墖鎴栨场楱扮墖褰㈠紡锛屾柟渚垮悶鍜藉洶闆ｆ垨鍏掔鎮ｈ€呬娇鐢�锛涢倓鏈変竴浜涚敘(ch菐n)鍝佸墖閲囩敤浜嗘鐗╂彁鍙栫墿鏇夸唬鍌崇当(t菕ng)鍖栧(xu茅)鎴愬垎锛屼互婊胯冻灏嶅ぉ鐒剁檪娉曟湁鍋忓ソ鐨勪汉缇ら渶姹�銆�

鍥涖€佸京(f霉)鍚堟姉鐕掑績鍔戠殑鐢�(ch菐n)鍝佸弮鏁�(sh霉)瑭宠В

鐐轰簡鏇寸洿瑙€鍦颁簡瑙ｅ京(f霉)鍚堟姉鐕掑績鍔戠殑鍚勯爡鎬ц兘鎸囨(bi膩o)锛屾垜鍊戝皣寰炰互涓嬪咕鍊嬫柟闈㈠皪鍏剁敘(ch菐n)鍝佸弮鏁�(sh霉)閫�(j矛n)琛岃┏绱�(x矛)瑙ｆ瀽锛�

锛堜竴锛変富瑕佹垚鍒嗗強鍏跺惈閲�

锛堜簩锛夊姂鍨嬭垏瑕�(gu墨)鏍�

寰�(f霉)鍚堟姉鐕掑績鍔戠殑鍔戝瀷澶氭ǎ锛屽寘鎷墖鍔戙€佽啝鍥�銆侀绮�銆佸彛鏈嶆恫绛夛紝姣忕ó鍔戝瀷閮芥湁鍏剁崹(d煤)鐗圭殑鍎�(y艒u)鍕細

锛堜笁锛夋帹钖︾敤娉曡垏娉ㄦ剰浜嬮爡

浜�銆佸京(f霉)鍚堟姉鐕掑績鍔戠殑鑷ㄥ簥鎳�(y墨ng)鐢ㄨ垏鐮旂┒閫�(j矛n)灞�

锛堜竴锛夎嚚搴婄檪鏁堣⿻浼�

澶氶爡鑷ㄥ簥鐮旂┒琛ㄦ槑锛屽京(f霉)鍚堟姉鐕掑績鍔戝湪娌荤檪鐕掑績鍙婄浉闂�(gu膩n)鐤剧梾鏂归潰琛ㄧ従(xi脿n)鍑鸿壊銆備緥濡�锛屼竴闋呯櫦(f膩)琛ㄤ簬銆奐ournal of Gastroenterology銆嬬殑鐮旂┒椤ず锛屼娇鐢ㄥ惈鏈夊ェ缇庢媺鍞戝拰閶呴洟瀛愮殑寰�(f霉)鍚堟姉鐕掑績鍔戞不鐧傝儍椋熺鍙嶆祦鐥呮偅鑰�锛屽叾鐧ョ媭绶╄В鐜囬珮閬�(d谩)90%锛屼笖寰�(f霉)鐧�(f膩)鐜囨槑椤綆浜庡柈绱斾娇鐢≒PIs鐨勫皪鐓х祫銆�

姝ゅ锛屽京(f霉)鍚堟姉鐕掑績鍔戝湪鍏掔闋�(l菒ng)鍩熺殑鎳�(y墨ng)鐢ㄤ篃鍙栧緱浜嗙⿳妤垫垚鏋�銆傚痉鍦嬬殑涓€闋呴毃姗�(j墨)灏嶇収瑭﹂鐧�(f膩)鐝�(xi脿n)锛屽皥鐐哄厭绔ヨō(sh猫)瑷堢殑鍜€鍤肩墖鍨嬪京(f霉)鍚堟姉鐕掑績鍔戜笉鍍呭畨鍏ㄦ€ч珮锛岃€屼笖鑳介’钁楁敼鍠勫姛鑳芥€ф秷鍖栦笉鑹偅鍏掔殑鐧ョ媭瑭曞垎銆�

锛堜簩锛夊湅鍏�(n猫i)澶栫爺绌剁従(xi脿n)鐙€

杩戝勾渚�锛屽湅鍏�(n猫i)澶栧(xu茅)鑰呭湇绻炲京(f霉)鍚堟姉鐕掑績鍔戝睍闁嬩簡澶ч噺鐮旂┒銆備互涓嬫槸閮ㄥ垎浠ｈ〃鎬х爺绌舵垚鏋滅殑绺界祼(ji茅)锛�

鍏�銆佸京(f霉)鍚堟姉鐕掑績鍔戠殑甯傚牬鍓嶆櫙鑸囩櫦(f膩)灞曟(j墨)閬�

闅ㄨ憲鍏ㄧ悆浜哄彛鑰侀健鍖栧姞鍔囦互鍙婄敓娲绘柟寮忕浉闂�(gu膩n)鐤剧梾鐨勫澶氾紝寰�(f霉)鍚堟姉鐕掑績鍔戠殑甯傚牬闇€姹傚皣鎸佺簩(x霉)鎿�(ku貌)澶�銆傛摎(j霉)鍦嬮殯甯傚牬鐮旂┒姗�(j墨)妲�(g貌u)闋�(y霉)娓紝鍒�2030骞�锛屽叏鐞冩姉鐕掑績钘ョ墿甯傚牬瑕�(gu墨)妯℃湁鏈涚獊鐮�300鍎勭編鍏�锛屽叾涓京(f霉)鍚堟姉鐕掑績鍔戠殑鍗犳瘮闋�(y霉)瑷堝皣瓒呴亷60%銆�

鐒惰€�锛岄€欎竴闋�(l菒ng)鍩熶粛闈㈣嚚璜稿鎸戞埌(zh脿n)銆備緥濡�锛屽浣曢€�(j矛n)涓€姝ュ劒(y艒u)鍖栬棩鐗╅厤鏂逛互娓涘皯鑰愯棩鎬у晱椤�锛熷浣曢枊鐧�(f膩)鏇村叿鍊嬫€у寲鐨勭敘(ch菐n)鍝佷互婊胯冻涓嶅悓浜虹兢鐨勯渶姹�锛熼€欎簺鍟忛閮介渶瑕佺鐮斾汉鍝″拰浼佹キ(y猫)鍏卞悓鍔姏鎵嶈兘瑙ｆ焙銆�

鍚屾檪锛屾垜鍊戜篃鎳�(y墨ng)鐪嬪埌锛屽京(f霉)鍚堟姉鐕掑績鍔戠殑鐧�(f膩)灞曚笉鍍呭儏灞€闄愪簬钘ュ搧鏈韩锛岄倓鍙互寤朵几鍒板仴搴风鐞嗘湇鍕�(w霉)銆佹櫤鑳界┛鎴磋ō(sh猫)鍌欑瓑澶氬€嬮牁(l菒ng)鍩�銆傛湭渚嗭紝閫氶亷澶ф暩(sh霉)鎿�(j霉)鍒嗘瀽鍜屼汉宸ユ櫤鑳芥妧琛�(sh霉)锛屾垜鍊戝彲浠ュ鐝�(xi脿n)灏嶇噿蹇冩偅鑰呯殑绮炬簴(zh菙n)瑷烘柗鍜屽€嬫€у寲娌荤檪鏂规鍒跺畾锛岀湡姝ｅ鐝�(xi脿n)寰炩€滄不鐥呪€濆埌鈥滄不鏈梾鈥濈殑杞�(zhu菐n)璁�銆�

涓�銆佺祼(ji茅)瑾烇細灞曟湜寰�(f霉)鍚堟姉鐕掑績鍔戠殑缇庡ソ鏈締

寰�(f霉)鍚堟姉鐕掑績鍔戜綔鐐烘柊涓€浠ｆ姉鐕掑績钘ョ墿鐨勪唬琛�锛屾啈鍊熷叾鍗撹秺鐨勭檪鏁堝拰寤ｆ硾鐨勬噳(y墨ng)鐢ㄥ墠鏅�锛屾鍦ㄩ€愭鏀硅畩?n猫i)钘楀厞鎱曘€戝€掕娋鐭哥粸?銆傚畠涓嶅儏鏄竴椤嗗皬灏忕殑钘ヤ父锛屾洿鏄従(xi脿n)浠ｇ鎶€鑸囦汉椤炴櫤鎱х浉绲�(ji茅)鍚堢殑绲�(ji茅)鏅�銆傛濡備竴浣嶈憲鍚嶇瀛�(xu茅)瀹舵墍瑾細鈥滅瀛�(xu茅)鐨勯€�(j矛n)姝ヤ笉鏄偤浜嗗埗閫犳洿澶氱殑钘ョ墿锛岃€屾槸鐐轰簡璁撴洿澶氱殑浜烘搧鏈夊仴搴风殑鐢熸椿?锛佹瘯鍢堟梺璇撶棯鐜喍顣�?锛屽京(f霉)鍚堟姉鐕掑績鍔戝皣鎴愮偤姣忎竴鍊嬪搴棩绠变腑鐨勫繀鍌欎箣閬�锛岀偤浜哄€戝付渚嗘洿鍔犺垝閬�銆佸仴搴风殑缇庡ソ鐢熸椿锛�

鎿�(ku貌)灞曢柋璁€:https://www.cyclohexylamine.net/cas-7646-78-8-anhydrous-tin-tetrachloride/

鎿�(ku貌)灞曢柋璁€:https://www.cyclohexylamine.net/delayed-equilibrium-catalyst-dabco-catalyst/

鎿�(ku貌)灞曢柋璁€:https://www.newtopchem.com/archives/39814

鎿�(ku貌)灞曢柋璁€:https://www.bdmaee.net/chloriddi-n-butylcinicity/

鎿�(ku貌)灞曢柋璁€:https://www.bdmaee.net/wp-content/uploads/2016/06/Niax-A-1-MSDS.pdf

鎿�(ku貌)灞曢柋璁€:https://www.morpholine.org/pc-cat-ncm-polyester-sponge-catalyst-dabco-ncm/

鎿�(ku貌)灞曢柋璁€:https://www.bdmaee.net/wp-content/uploads/2021/05/3-9.jpg

鎿�(ku貌)灞曢柋璁€:https://www.newtopchem.com/archives/938

鎿�(ku貌)灞曢柋璁€:https://www.bdmaee.net/syl-off-7923-catalyst-cas68844-81-7-dow/

鎿�(ku貌)灞曢柋璁€:https://www.newtopchem.com/archives/1891