涓€銆佽仛姘ㄩ叝鍌寲鍔慏MAP锛氶珮鎬ц兘瀵嗗皝鑶犺儗鍚庣殑绉樺瘑姝﹀櫒

鍦ㄧ従(xi脿n)浠ｅ伐妤�(y猫)鍜屽缓绛戦牁(l菒ng)鍩燂紝楂樻€ц兘瀵嗗皝鑶犲凡鎴愮偤涓嶅彲鎴栫己鐨勯棞(gu膩n)閸垫潗鏂�銆傚緸楂樻〒澶у粓鐨勭幓鐠冨箷澧诲埌姹借粖鍒堕€犱腑鐨勮粖韬瘑灏�锛屽啀鍒伴浕瀛愯ō(sh猫)鍌欎腑鐨勯槻姘撮槻濉佃檿鐞嗭紝瀵嗗皝鑶犱互鍏跺崜瓒婄殑绮樺悎鎬ц兘鍜岃€愬€欐€�锛岀偤鎴戝€戠殑鐢熸椿鎻愪緵浜嗗彲闈犵殑淇濋殰銆傝€屽湪閫欎簺楂樻€ц兘瀵嗗皝鑶犵殑鑳屽悗锛屾湁涓€椤炵濂囩殑鍖栧(xu茅)鐗╄唱(zh矛)鈥斺€旇仛姘ㄩ叝鍌寲鍔�锛屽湪鍏朵腑鐧�(f膩)鎻憲鑷抽棞(gu膩n)閲嶈鐨勪綔鐢�銆傝€孌MAP锛�4-浜岀敳姘ㄥ熀鍚″暥锛夋鏄€欓鍌寲鍔戜腑鐨勪郊浣艰€�銆�

DMAP鏄竴绋櫧鑹茬祼(ji茅)鏅舵€х矇鏈紝鍖栧(xu茅)寮忕偤C7H10N2锛岀啍榛為珮閬�(d谩)148鈩�锛屽叿鏈夊劒(y艒u)鐣扮殑鐔辩┅(w臎n)瀹氭€у拰鍖栧(xu茅)绌�(w臎n)瀹氭€с€備綔鐐轰竴椤為珮鏁堝偓鍖栧姂锛孌MAP鍦ㄨ仛姘ㄩ叝鍙嶆噳(y墨ng)涓壆婕旇憲"绱呭"鐨勮鑹�锛岄€氶亷淇冮€茬暟姘伴吀閰垏澶氬厓閱囦箣闁撶殑鍙嶆噳(y墨ng)锛岄’钁楁彁鍗囧弽鎳�(y墨ng)閫熺巼鍜岀敘(ch菐n)鐗╂€ц兘銆傚叾鐛ㄧ壒鐨勫垎瀛愮祼(ji茅)妲�(g貌u)璩︿簣浜嗗畠妤靛挤鐨勫牽鎬�锛屼娇鍏惰兘澶犳湁鏁堝湴娲诲寲鐣版鞍閰搁叝鍩哄湗锛屽緸鑰屽姞閫熻仛姘ㄩ叝鐨勫舰鎴愰亷绋�銆�

鍦ㄥ闅涙噳(y墨ng)鐢ㄤ腑锛孌MAP鐨勫姞鍏ヤ笉鍍呰兘澶犵府鐭瘑灏佽啝鐨勫浐鍖栨檪闁�锛岄倓鑳芥湁鏁堟敼鍠勭祩鐢�(ch菐n)鍝佺殑鍔涘(xu茅)鎬ц兘鍜岃€愪箙鎬с€傝垏鍌崇当(t菕ng)鐨勯尗椤炲偓鍖栧姂鐩告瘮锛孌MAP灞曠従(xi脿n)鍑烘洿鍎�(y艒u)鐨勯伕鎿囨€у拰鏇撮珮鐨勬椿鎬�锛岃兘澶犲湪鏇翠綆鐨勭敤閲忎笅瀵︾従(xi脿n)鐞嗘兂鐨勫偓鍖栨晥鏋溿€傞€欑ó鐗规€т娇寰桪MAP鎴愮偤鐝�(xi脿n)浠ｉ珮鎬ц兘瀵嗗皝鑶犻厤鏂逛腑涓嶅彲鎴栫己鐨勯棞(gu膩n)閸电祫鍒嗕箣涓€銆�

鏈枃灏囨繁鍏ユ帰瑷嶥MAP鍦ㄨ仛姘ㄩ叝瀵嗗皝鑶犱腑鐨勫叿楂斾綔鐢ㄦ鍒�锛屽垎鏋愬叾灏嶇敘(ch菐n)鍝佹€ц兘鐨勫奖闊�锛屽苟绲�(ji茅)鍚堝闅涙渚嬮棥杩板叾鍦ㄤ笉鍚屾噳(y墨ng)鐢ㄥ牬鏅笅鐨勮〃鐝�(xi脿n)銆傚悓鏅�锛屾垜鍊戝皣瑭崇窗(x矛)浠嬬垂DMAP鐨勭敘(ch菐n)鍝佸弮鏁�(sh霉)銆佷娇鐢ㄦ敞鎰忎簨闋呭強鏈締鐧�(f膩)灞曟柟鍚�锛屽公鍔╄畝鑰呭叏闈㈢悊瑙ｉ€欎竴闂�(gu膩n)閸靛寲瀛�(xu茅)鍝佸湪鐝�(xi脿n)浠ｅ瘑灏佽啝鎶€琛�(sh霉)涓殑閲嶈鍦颁綅銆�

浜屻€丏MAP鐨勫熀鏈壒鎬ц垏鍙嶆噳(y墨ng)姗熺悊

2.1 DMAP鐨勭墿鐞嗗寲瀛�(xu茅)鎬ц唱(zh矛)

DMAP浣滅偤涓€绋噸瑕佺殑鏈夋鍌寲鍔�锛屽叾鍩烘湰鐗╃悊鍖栧(xu茅)鎬ц唱(zh矛)姹哄畾浜嗗叾鍦ㄨ仛姘ㄩ叝楂旂郴涓殑鎳�(y墨ng)鐢ㄧ壒鎬с€傝┎鍖栧悎鐗╁憟鐧借壊閲濈媭鏅堕珨褰㈡厠(t脿i)锛屽叿鏈夎壇濂界殑鍖栧(xu茅)绌�(w臎n)瀹氭€у拰鐔辩┅(w臎n)瀹氭€э紝鐔旈粸鐐�148鈩�锛屾哺榛�360鈩冿紙鍒嗚В锛�锛屽瘑搴︾偤1.18 g/cm3銆侱MAP鐨勬憾瑙ｆ€х壒寰佸挨鐐虹獊鍑猴紝瀹冨湪甯歌鏈夋婧跺姂濡�銆佷簩姘敳鐑�銆佺瓑涓潎琛ㄧ従(xi脿n)鍑鸿壇濂界殑婧惰В鑳藉姏锛岄€欑偤鍏跺湪鑱氭皑閰弽鎳�(y墨ng)楂旂郴涓殑鍧囧嫽鍒嗘暎鎻愪緵浜嗘湁鍒╂浠�銆�

琛�1锛欴MAP鐨勪富瑕佺墿鐞嗗寲瀛�(xu茅)鍙冩暩(sh霉)

DMAP鍏锋湁杓冨挤鐨勫牽鎬э紝pKa鍊肩磩鐐�5.3锛岄€欎娇鍏惰兘澶犳湁鏁堟椿鍖栫暟姘伴吀閰熀鍦橈紝淇冮€茶仛姘ㄩ叝鍙嶆噳(y墨ng)鐨勯€茶銆傚叾鐛ㄧ壒鐨勫悺鍟剁挵(hu谩n)绲�(ji茅)妲�(g貌u)璩︿簣浜嗗垎瀛愯純楂樼殑鍏辫粵鏁堟噳(y墨ng)锛屽寮蜂簡鍏堕浕瀛愪緵绲﹁兘鍔�锛屽緸鑰屼娇DMAP鍦ㄥ偓鍖栭亷绋嬩腑琛ㄧ従(xi脿n)鍑哄劒(y艒u)鐣扮殑娲绘€�銆�

2.2 鍙嶆噳(y墨ng)姗熺悊鍓栨瀽

DMAP鍦ㄨ仛姘ㄩ叝鍙嶆噳(y墨ng)涓殑鍌寲姗熺悊涓昏娑夊強浠ヤ笅骞惧€嬫椹燂細

棣栧厛锛孌MAP閫氶亷鍏舵爱鍘熷瓙涓婄殑瀛ゅ皪闆诲瓙鑸囩暟姘伴吀閰熀鍦橈紙-NCO锛夌櫦(f膩)鐢熺浉浜掍綔鐢紝褰㈡垚绌�(w臎n)瀹氱殑绲�(lu貌)鍚堢墿銆傞€欎竴閬庣▼椤憲闄嶄綆浜嗙暟姘伴吀閰熀鍦樼殑闆昏矤(f霉)鎬�锛屼娇鍏舵洿瀹规槗鑸囩茎鍩猴紙-OH锛夋垨鑳哄熀锛�-NH2锛夌瓑娲绘€ф矮鐧�(f膩)鐢熷弽鎳�(y墨ng)銆�

鍏舵锛屽舰鎴愮殑涓枔楂旈€氶亷閬庢浮鎱�(t脿i)閫蹭竴姝ヨ綁(zhu菐n)鍖栫偤鑱氭皑閰張娈�銆傚湪閫欏€嬮亷绋嬩腑锛孌MAP涓嶅儏鍏呯暥(d膩ng)浜嗛浕瀛愪緵楂旂殑瑙掕壊锛岄倓閫氶亷绌洪枔浣嶉樆鏁堟噳(y墨ng)瑾�(di脿o)鎺т簡鍙嶆噳(y墨ng)鐨勬柟鍚戞€�锛岀⒑淇濈敓鎴愮洰妯�(bi膩o)鐢�(ch菐n)鐗╄€岄潪鍓敘(ch菐n)鐗�銆�

鍚�锛孌MAP鍦ㄥ畬鎴愬偓鍖栦换鍕�(w霉)鍚庝互娓搁洟鐙€鎱�(t脿i)瀛樺湪锛屽彲绻肩簩(x霉)鍙冭垏鏂扮殑鍌寲寰挵(hu谩n)銆傞€欑ó鍙€嗙殑鍌寲姗熷埗浣緿MAP鑳藉鍦ㄨ純浣庢績搴︿笅瀵︾従(xi脿n)楂樻晥鐨勫偓鍖栨晥鏋�銆�

鍊煎緱娉ㄦ剰鐨勬槸锛孌MAP鐨勫偓鍖栦綔鐢ㄥ叿鏈夋槑椤殑閬告搰鎬х壒寰�銆傚湪澶氬畼鑳藉湗楂旂郴涓�锛孌MAP鍎�(y艒u)鍏堜績閫茬暟姘伴吀閰垏缇ュ熀鐨勫弽鎳�(y墨ng)锛岃€岄潪鑳哄熀鐨勫弽鎳�(y墨ng)銆傞€欑ó閬告搰鎬у皪浜庢帶鍒惰仛姘ㄩ叝鏉愭枡鐨勪氦鑱�(li谩n)瀵嗗害鍜岀祩鎬ц兘鑷抽棞(gu膩n)閲嶈銆�

姝ゅ锛孌MAP鐨勫偓鍖栨晥鐜囬倓鍙楀埌鍙嶆噳(y墨ng)鐠�(hu谩n)澧冨洜绱犵殑褰遍熆銆傛韩搴﹀崌楂橀€氬父鏈冨姞蹇偓鍖栧弽鎳�(y墨ng)閫熺巼锛屼絾閬庨珮鐨勬韩搴﹀彲鑳藉皫(d菐o)鑷碊MAP鍒嗚В锛涙憾鍔戠殑閬告搰涔熸渻褰遍熆DMAP鐨勬憾瑙ｅ害鍜屽垎鏁ｆ€�锛岄€茶€屽奖闊垮叾鍌寲鏁堟灉銆傚洜姝�锛屽湪瀵﹂殯鎳�(y墨ng)鐢ㄤ腑闇€瑕佺稖鍚堣€冩叜鍚勭ó鍥犵礌锛屽劒(y艒u)鍖栧弽鎳�(y墨ng)姊濅欢浠ュ厖鍒嗙櫦(f膩)鎻瓺MAP鐨勫偓鍖栨晥鑳姐€�

涓�銆丏MAP鍦ㄨ仛姘ㄩ叝瀵嗗皝鑶犱腑鐨勭崹鐗瑰劒(y艒u)鍕�

3.1 鎻愬崌鍙嶆噳(y墨ng)鏁堢巼

鍦ㄨ仛姘ㄩ叝瀵嗗皝鑶犵殑鍒跺倷閬庣▼涓�锛孌MAP灞曠従(xi脿n)鍑轰簡椤憲鐨勫弽鎳�(y墨ng)鍔犻€熶綔鐢�銆傝垏鍌崇当(t菕ng)鍌寲鍔戠浉姣�锛孌MAP鑳藉?q奴)鈷庣；?y墨ng)鏅傞枔绺煭绱�30%-50%锛岄€欏皪浜庢彁楂樼敓鐢�(ch菐n)鏁堢巼鍏锋湁閲嶈鎰忕京銆傚椹楁暩(sh霉)鎿�(j霉)椤ず锛屽湪鐩稿悓鐨勫弽鎳�(y墨ng)姊濅欢涓�锛屼娇鐢―MAP鍌寲鐨勮仛姘ㄩ叝楂旂郴鍙互鍦�3-5灏忔檪鍏�(n猫i)瀹屾垚鍥哄寲锛岃€屽偝绲�(t菕ng)鍌寲鍔戝墖闇€瑕�8-12灏忔檪銆�

閫欑ó楂樻晥鐨勫偓鍖栬兘鍔涙簮浜嶥MAP鐛ㄧ壒鐨勫垎瀛愮祼(ji茅)妲�(g貌u)銆傚叾鍚″暥鐠�(hu谩n)涓婄殑姘師瀛愬彲浠ヨ垏鐣版鞍閰搁叝鍩哄湗褰㈡垚寮风殑蟺-蟺鐩镐簰浣滅敤锛岄’钁楅檷浣庡弽鎳�(y墨ng)娲诲寲鑳姐€傚悓鏅�锛孌MAP鍏锋湁杓冮珮鐨勫牽鎬э紝鑳藉鏈夋晥娲诲寲鐣版鞍閰搁叝鍩哄湗锛屼績閫插叾鑸囧鍏冮唶鐨勫揩閫熷弽鎳�(y墨ng)銆傜爺绌惰〃鏄�锛屽湪鐩稿悓婵冨害涓�锛孌MAP鐨勫偓鍖栨晥鐜囨槸鍌崇当(t菕ng)閷鍌寲鍔戠殑2-3鍊�銆�

3.2 鏀瑰杽鐢�(ch菐n)鍝佹€ц兘

DMAP鐨勫姞鍏ヤ笉鍍呮彁鍗囦簡鍙嶆噳(y墨ng)鏁堢巼锛岄倓椤憲鏀瑰杽浜嗚仛姘ㄩ叝瀵嗗皝鑶犵殑绲傛€ц兘銆傞€氶亷绮剧⒑瑾�(di脿o)鎺у弽鎳�(y墨ng)閫茬▼锛孌MAP鑳藉淇冮€插舰鎴愭洿鍔犺(gu墨)鏁寸殑鑱氭皑閰恫(w菐ng)绲�(lu貌)绲�(ji茅)妲�(g貌u)锛屽緸鑰屾彁楂樻潗鏂欑殑姗熸寮峰害鍜屽綀鎬фā閲�銆傚椹楁暩(sh霉)鎿�(j霉)琛ㄦ槑锛屼娇鐢―MAP鍌寲鐨勮仛姘ㄩ叝瀵嗗皝鑶狅紝鍏舵媺浼稿挤搴﹀彲鎻愰珮25%浠ヤ笂锛屾柗瑁備几闀风巼澧炲姞30%-40%銆�

鏇撮噸瑕佺殑鏄�锛孌MAP鑳藉鏈夋晥娓涘皯鍓弽鎳�(y墨ng)鐨勭櫦(f膩)鐢燂紝闄嶄綆涓嶅繀瑕佷氦鑱�(li谩n)鐨勭▼搴�銆傞€欑ó閬告搰鎬у偓鍖栫壒鎬т娇寰楃祩鐢�(ch菐n)鍝佸叿鏈夋洿鍎�(y艒u)鐨勬煍闊屾€у拰鍥炲綀鎬�锛岀壒鍒ユ槸鍦ㄤ綆婧挵(hu谩n)澧冧笅浠嶈兘淇濇寔鑹ソ鐨勫綀鎬ф€ц兘銆傛澶�锛岀敱浜嶥MAP涓嶆渻寮曞叆閲戝爆闆㈠瓙锛岄伩鍏嶄簡鍙兘鐨勮厫铦曞晱椤�锛岄€欏皪浜庢煇浜涚壒娈婃噳(y墨ng)鐢ㄥ牬鍚堝挨鐐洪噸瑕�銆�

3.3 澧炲挤绮樻帴鎬ц兘

鍦ㄧ矘鎺ユ€ц兘鏂归潰锛孌MAP鍚屾ǎ琛ㄧ従(xi脿n)鍑鸿壊銆傞€氶亷淇冮€茬暟姘伴吀閰熀鍦樿垏鍩烘潗琛ㄩ潰娲绘€у熀鍦樼殑鍙嶆噳(y墨ng)锛孌MAP鑳藉椤憲鎻愰珮瀵嗗皝鑶犺垏鍚勭ó鍩烘潗鐨勭矘闄勫姏銆傚椹楃祼(ji茅)鏋滈’绀�锛岀稉(j墨ng)閬嶥MAP鏀规€х殑鑱氭皑閰瘑灏佽啝灏嶆贩鍑濆湡銆侀噾灞拰濉戞枡绛夊父瑕嬪熀鏉愮殑绮樻帴寮峰害鍙彁楂�30%-50%銆�

鐗瑰垾鍊煎緱涓€鎻愮殑鏄�锛孌MAP鐨勪娇鐢ㄩ倓鑳藉鏀瑰杽婵曟埃鍥哄寲鍨嬭仛姘ㄩ叝瀵嗗皝鑶犵殑鎬ц兘銆傚湪娼繒鐠�(hu谩n)澧冧腑锛孌MAP鑳藉鏈夋晥淇冮€茬暟姘伴吀閰垏姘村垎瀛愮殑鍙嶆噳(y墨ng)锛屽舰鎴愮┅(w臎n)瀹氱殑鑴查嵉绲�(ji茅)妲�(g貌u)锛屽緸鑰屾彁楂樺瘑灏佽啝鐨勮€愭按瑙ｆ€ц兘鍜岄暦鏈熺┅(w臎n)瀹氭€�銆傞€欑ó鐗规€т娇寰桪MAP鏀规€х殑瀵嗗皝鑶犵壒鍒ラ仼鍚堢敤浜庡缓绛戝澧�銆佹⿱姊佺瓑鎴跺鐠�(hu谩n)澧�銆�

3.4 鑹ソ鐨勫劜瀛樼┅(w臎n)瀹氭€�

鑸囧叾浠栭珮娲绘€у偓鍖栧姂鐩告瘮锛孌MAP鍏锋湁鏇村ソ鐨勫劜瀛樼┅(w臎n)瀹氭€�銆傚嵆浣垮湪杓冮珮婧害涓�锛孌MAP涔熶笉鏈冪櫦(f膩)鐢熸槑椤殑闄嶈В鎴栧け鏁�銆傚椹楃爺绌剁櫦(f膩)鐝�(xi脿n)锛孌MAP鍦ㄥ婧笅鍎插瓨涓€骞村悗锛屽叾鍌寲娲绘€т粛鍙繚鎸佸湪鍒濆姘村钩鐨�95%浠ヤ笂銆傞€欑ó鍎�(y艒u)鐣扮殑绌�(w臎n)瀹氭€у緱鐩婁簬鍏剁崹鐗圭殑鍒嗗瓙绲�(ji茅)妲�(g貌u)锛屼娇寰桪MAP鑳藉鍦ㄩ暦鏅傞枔鍎插瓨閬庣▼涓繚鎸佹椿鎬�锛岀偤鐢�(ch菐n)鍝佺殑璩�(zh矛)閲忔帶鍒舵彁渚涗簡鍙潬淇濋殰銆�

缍滀笂鎵€杩�锛孌MAP鍦ㄨ仛姘ㄩ叝瀵嗗皝鑶犱腑鐨勬噳(y墨ng)鐢ㄥ睍鐝�(xi脿n)浜嗗鏂归潰鐨勫劒(y艒u)鍕�锛屽叾楂樻晥鐨勫偓鍖栨€ц兘銆佸劒(y艒u)鐣扮殑鐢�(ch菐n)鍝佹敼鑹兘鍔涘拰鑹ソ鐨勫劜瀛樼┅(w臎n)瀹氭€�锛屼娇鍏舵垚鐐虹従(xi脿n)浠ｉ珮鎬ц兘瀵嗗皝鑶犻枊鐧�(f膩)涓殑鐞嗘兂閬告搰銆�

鍥�銆丏MAP鍦ㄤ笉鍚岄鍨嬪瘑灏佽啝涓殑鎳�(y墨ng)鐢ㄥ渚�

4.1 寤虹瓚鐢ㄨ仛姘ㄩ叝瀵嗗皝鑶�

鍦ㄥ缓绛戦牁(l菒ng)鍩�锛孌MAP鐨勬噳(y墨ng)鐢ㄥ凡鍙栧緱椤憲鎴愭晥銆備互鏌愮煡鍚嶅搧鐗岀殑闆欑祫浠借仛姘ㄩ叝骞曞⒒瀵嗗皝鑶犵偤渚嬶紝閫氶亷娣诲姞閬╅噺鐨凞MAP锛屾垚鍔熷鐝�(xi脿n)浜嗙敘(ch菐n)鍝佹€ц兘鐨勫叏闈㈡彁鍗�銆傝┎瀵嗗皝鑶犲湪鍥哄寲閬庣▼涓�锛孌MAP鑳藉鏈夋晥淇冮€茬暟姘伴吀閰垏澶氬厓閱囩殑鍙嶆噳(y墨ng)锛屼娇鍥哄寲鏅傞枔鐢卞師渚嗙殑8灏忔檪绺煭鑷�4灏忔檪浠ュ収(n猫i)锛屽ぇ骞呮彁楂樹簡鏂藉伐鏁堢巼銆傚悓鏅�锛屾敼閫插悗鐨勫瘑灏佽啝灏嶇幓鐠冦€侀媮鏉愮瓑寤虹瓚鏉愭枡鐨勭矘鎺ュ挤搴︽彁楂樹簡绱�40%锛屽苟涓斿湪-40鈩冭嚦80鈩冪殑婧害鑼冨湇鍏�(n猫i)浠嶈兘淇濇寔鑹ソ鐨勫綀鎬у拰瀵嗗皝鎬ц兘銆�

瀵﹂璀夋槑锛屽湪楂樺堡寤虹瓚骞曞⒒鏂藉伐涓紝浣跨敤鍚獶MAP鐨勮仛姘ㄩ叝瀵嗗皝鑶犺兘澶犻’钁楁笡灏戝洜婧樊寮曡捣鐨勯枊瑁傜従(xi脿n)璞�銆傜壒鍒ユ槸鍦ㄦ部娴峰湴鍗€(q奴)锛屾敼閫插悗鐨勫瘑灏佽啝琛ㄧ従(xi脿n)鍑烘洿寮风殑鎶楃传澶栫窔鑰佸寲鑳藉姏鍜岃€愰菇闇ц厫铦曟€ц兘锛屼娇鐢ㄥ＝鍛藉欢闀疯嚦鏅€氱敘(ch菐n)鍝佺殑1.5鍊嶄互涓娿€傞€欑ó鎬ц兘鎻愬崌涓嶅儏闄嶄綆浜嗙董璀锋垚鏈�锛岄倓鎻愰珮浜嗗缓绛戠墿鐨勬暣楂斿畨鍏ㄦ€у拰缇庤搴︺€�

4.2 宸ユキ(y猫)鐢ㄨ仛姘ㄩ叝瀵嗗皝鑶�

鍦ㄥ伐妤�(y猫)鎳�(y墨ng)鐢ㄦ柟闈�锛孌MAP鍚屾ǎ灞曠従(xi脿n)浜嗗崜瓒婄殑鍍瑰€笺€備緥濡�锛屽湪姹借粖鍒堕€犻牁(l菒ng)鍩�锛屾煇鍦嬮殯鍝佺墝閲囩敤鍚湁DMAP鐨勫柈绲勪唤婵曟埃鍥哄寲鑱氭皑閰瘑灏佽啝锛岀敤浜庤粖韬剨鎺ラ儴浣嶇殑瀵嗗皝铏曠悊銆傞€欑ó瀵嗗皝鑶犲湪鍣存秱鍚�24灏忔檪鍏�(n猫i)鍗冲彲閬�(d谩)鍒板垵姝ュ浐鍖�锛屽畬鍏ㄥ浐鍖栨檪闁撶府鐭嚦48灏忔檪锛屾瘮鍌崇当(t菕ng)鐢�(ch菐n)鍝佸揩浜嗕竴鍊嶃€傛洿鐐洪噸瑕佺殑鏄�锛屾敼閫插悗鐨勫瘑灏佽啝鍦ㄥ嫊鎱�(t脿i)璨�(f霉)杓夋脯瑭︿腑琛ㄧ従(xi脿n)鍑烘洿寮风殑鎶楁挄瑁傛€ц兘锛屾挄瑁傚挤搴︽彁楂樹簡35%銆�

鐗瑰垾鏄湪鏂拌兘婧愭苯杌婇浕姹犲寘瀵嗗皝鎳�(y墨ng)鐢ㄤ腑锛屽惈DMAP鐨勮仛姘ㄩ叝瀵嗗皝鑶犲睍鐝�(xi脿n)浜嗗劒(y艒u)鐣扮殑闆绘埃绲曠罚鎬ц兘鍜岃€愬寲瀛�(xu茅)鑵愯潟鑳藉姏銆傚椹楁暩(sh霉)鎿�(j霉)椤ず锛岃┎瀵嗗皝鑶犲湪缍�(j墨ng)閬�1000灏忔檪鐨勯菇闇ф脯瑭﹀悗锛屼粛鐒朵繚鎸佽壇濂界殑瀵嗗皝鏁堟灉锛屾湭鍑虹従(xi脿n)浠讳綍娉勬紡鎴栨€ц兘涓嬮檷鐝�(xi脿n)璞�銆傞€欑ó鍙潬鎬у皪浜庣⒑淇濋浕姹犵郴绲�(t菕ng)鐨勫畨鍏ㄩ亱琛岃嚦闂�(gu膩n)閲嶈銆�

4.3 闆诲瓙鍣ㄤ欢鐢ㄨ仛姘ㄩ叝瀵嗗皝鑶�

鍦ㄧ簿瀵嗛浕瀛愬櫒浠堕牁(l菒ng)鍩燂紝DMAP鐨勬噳(y墨ng)鐢ㄥ付渚嗕簡闈╁懡鎬х殑閫叉銆傛煇鐭ュ悕鍗婂皫(d菐o)楂斿埗閫犲晢閲囩敤鍚獶MAP鐨勪綆绮樺害鑱氭皑閰瘑灏佽啝锛岀敤浜庤姱鐗囧皝瑁濆拰鍌虫劅鍣ㄤ繚璀�銆傞€欑ó瀵嗗皝鑶犲湪榛炶啝鍚庤兘鍦�3-5鍒嗛悩鍏�(n猫i)瀵︾従(xi脿n)鍒濇瀹氫綅锛屽畬鍏ㄥ浐鍖栨檪闁撳儏鐐�2灏忔檪锛屽ぇ澶ф彁楂樹簡鐢熺敘(ch菐n)鏁堢巼銆傚悓鏅�锛屾敼閫插悗鐨勫瘑灏佽啝鍏锋湁鏇翠綆鐨勬彯鐧�(f膩)鎬ф湁姗熷寲鍚堢墿锛圴OC锛夊惈閲�锛屾豢瓒充簡鐠�(hu谩n)淇濊姹�銆�

鐗瑰垾鍊煎緱涓€鎻愮殑鏄�锛屽惈DMAP鐨勯浕瀛愮礆鑱氭皑閰瘑灏佽啝鍦ㄩ珮婧珮婵曠挵(hu谩n)澧冧笅琛ㄧ従(xi脿n)鍑哄劒(y艒u)鐣扮殑灏哄绌�(w臎n)瀹氭€�銆傚湪缍�(j墨ng)閬�200娆℃韩搴﹀惊鐠�(hu谩n)娓│锛�-55鈩冭嚦125鈩冿級鍚�锛屽瘑灏佽啝浠嶆湭鍑虹従(xi脿n)浠讳綍闁嬭鎴栧墲钀界従(xi脿n)璞�銆傞€欑ó鍙潬鎬у皪浜庣⒑淇濋浕瀛愬櫒浠剁殑闀锋湡绌�(w臎n)瀹氶亱琛屽叿鏈夐噸瑕佹剰缇┿€�

4.4 瀹跺眳瑁濋＞鐢ㄨ仛姘ㄩ叝瀵嗗皝鑶�

鍦ㄥ瑁濆競鍫�锛孌MAP鐨勬噳(y墨ng)鐢ㄤ篃鍙栧緱浜嗛’钁楁垚鏁堛€傛煇鍦嬪収(n猫i)鐭ュ悕鍝佺墝鎺ㄥ嚭鐨勫粴鎴胯(w猫i)鐢熼枔灏堢敤鑱氭皑閰瘑灏佽啝锛岄€氶亷娣诲姞DMAP瀵︾従(xi脿n)浜嗙敘(ch菐n)鍝佹€ц兘鐨勫叏闈㈡彁鍗�銆傝┎瀵嗗皝鑶犲湪鏂藉伐鍚�2灏忔檪鍏�(n猫i)鍗冲彲閬�(d谩)鍒板垵姝ュ浐鍖栵紝瀹屽叏鍥哄寲鏅傞枔绺煭鑷�24灏忔檪浠ュ収(n猫i)銆傛敼閫插悗鐨勫瘑灏佽啝灏嶇摲纾氥€佷笉閵归嫾绛夊父瑕嬭淇潗鏂欑殑绮樻帴寮峰害鎻愰珮浜嗙磩30%锛屽苟涓斿叿鏈夋洿寮风殑闃查湁鎶楄弻鑳藉姏銆�

鐗瑰垾鏄湪娼繒鐠�(hu谩n)澧冧腑锛屽惈DMAP鐨勮仛姘ㄩ叝瀵嗗皝鑶犺〃鐝�(xi脿n)鍑哄劒(y艒u)鐣扮殑鑰愭按瑙ｆ€ц兘銆傚椹楁暩(sh霉)鎿�(j霉)椤ず锛岀稉(j墨ng)閬�1000灏忔檪鐨勬蹈姘存脯瑭﹀悗锛屽瘑灏佽啝浠嶆湭鍑虹従(xi脿n)浠讳綍鎬ц兘涓嬮檷鐝�(xi脿n)璞°€傞€欑ó鍙潬鎬у皪浜庣⒑淇濆瑁濆伐绋嬬殑璩�(zh矛)閲忓拰浣跨敤澹藉懡鑷抽棞(gu膩n)閲嶈銆�

浜斻€丏MAP鐨勭敘(ch菐n)鍝佸弮鏁�(sh霉)鑸囨妧琛�(sh霉)鎸囨(bi膩o)

鐐轰簡鏇村ソ鍦扮悊瑙ｅ拰鎳�(y墨ng)鐢―MAP锛屾垜鍊戦渶瑕佹繁鍏ヤ簡瑙ｅ叾瑭崇窗(x矛)鐨勭敘(ch菐n)鍝佸弮鏁�(sh霉)鍜屾妧琛�(sh霉)鎸囨(bi膩o)銆備互涓嬭〃鏍煎尟绺戒簡DMAP鐨勯棞(gu膩n)閸垫妧琛�(sh霉)鍙冩暩(sh霉)锛岀偤浣跨敤鑰呮彁渚涚瀛�(xu茅)鐨勫弮鑰冧緷鎿�(j霉)銆�

琛�2锛欴MAP鐨勬妧琛�(sh霉)鍙冩暩(sh霉)琛�

5.1 浣跨敤娉ㄦ剰浜嬮爡

鍦ㄥ闅涙噳(y墨ng)鐢ㄤ腑锛屾纰轰娇鐢―MAP灏嶄簬鐧�(f膩)鎻叾浣虫€ц兘鑷抽棞(gu膩n)閲嶈銆備互涓嬫槸骞惧€嬮棞(gu膩n)閸电殑浣跨敤寤鸿锛�

1. 娣诲姞閲忔帶鍒讹細涓€鑸帹钖︽坊鍔犻噺鐐虹附閰嶆柟閲忕殑0.01%-0.1%锛屽叿楂旂敤閲忛渶鏍规摎(j霉)鍙嶆噳(y墨ng)楂旂郴鍜岀敘(ch菐n)鍝佹€ц兘瑕佹眰閫茶瑾�(di脿o)鏁�銆傞亷閲忎娇鐢ㄥ彲鑳藉皫(d菐o)鑷村弽鎳�(y墨ng)澶辨帶鎴栫敘(ch菐n)鐢熼亷澶氬壇鐢�(ch菐n)鐗┿€�

2. 鍒嗘暎鍧囧嫽鎬э細DMAP鎳�(y墨ng)鍏呭垎鍒嗘暎鍦ㄥ弽鎳�(y墨ng)楂旂郴涓�锛屽缓璀伴噰鐢ㄩ珮閫熸敧鎷屾垨瓒呰伈娉㈠垎鏁ｆ妧琛�(sh霉)锛岀⒑淇濆叾鍧囧嫽鍒嗗竷锛岄伩鍏嶅眬閮ㄦ績搴﹂亷楂樸€�

3. 婧害鎺у埗锛氶仼瀹滅殑鍙嶆噳(y墨ng)婧害鑼冨湇鐐�40-80鈩�锛岄亷楂樻韩搴﹀彲鑳藉皫(d菐o)鑷碊MAP鍒嗚В锛屽奖闊垮叾鍌寲鏁堟灉銆�

4. 鍎插瓨姊濅欢锛氭噳(y墨ng)瀵嗗皝淇濆瓨鍦ㄥ共鐕ラ櫚娑艰檿锛岄伩鍏嶉櫧鍏夌洿灏�锛屽劜瀛樻韩搴︿笉瀹滆秴閬�30鈩冿紝浠ラ槻姝㈠惛娼垨闄嶈В銆�

5. 閰嶄紞鎬э細鍦ㄤ娇鐢ㄥ墠闇€閫茶閰嶄紞鎬ц│椹�锛岀⒑淇滵MAP鑸囧叾浠栧姪鍔戝拰鍘熸枡鐩稿锛岄伩鍏嶄笉鑹弽鎳�(y墨ng)鎴栨€ц兘涓嬮檷銆�

6. 瀹夊叏闃茶锛氭搷浣滄檪鎳�(y墨ng)浣╂埓閬╃暥(d膩ng)?sh霉)鑶偓浜洪槻璀疯鍌�锛岄伩鍏嶇洿鎺ユ帴瑙哥毊鑶氬拰鍚稿叆绮夊〉锛岄伒寰浉闂�(gu膩n)瀹夊叏鎿嶄綔瑕�(gu墨)绋�銆�

5.2 鎬ц兘鍎�(y艒u)鍖栫瓥鐣�

鐐轰簡閫蹭竴姝ュ劒(y艒u)鍖朌MAP鍦ㄨ仛姘ㄩ叝楂旂郴涓殑鎳�(y墨ng)鐢ㄦ晥鏋�锛屽彲浠ュ緸浠ヤ笅骞惧€嬫柟闈㈠叆鎵嬶細

1. 绲�(ji茅)妲�(g貌u)淇＞锛氶€氶亷灏岲MAP鍒嗗瓙閫茶鍔熻兘鍖栨敼鎬э紝鍙互鏀瑰杽鍏舵憾瑙ｆ€ф垨閬告搰鎬�锛岄仼鎳�(y墨ng)鐗瑰畾鎳�(y墨ng)鐢ㄩ渶姹�銆�

2. 寰�(f霉)閰嶄娇鐢細鑸囧叾浠栭鍨嬪偓鍖栧姂寰�(f霉)閰嶄娇鐢紝鍙互瀵︾従(xi脿n)鍗�(xi茅)鍚屾晥鎳�(y墨ng)锛屽劒(y艒u)鍖栧弽鎳�(y墨ng)鍕曞姏瀛�(xu茅)鍜岀敘(ch菐n)鍝佹€ц兘銆�

3. 寰啝鍥婂寲锛氬皣DMAP鍒舵垚寰啝鍥婂舰寮�锛屽彲浠ユ帶鍒堕噵鏀鹃€熷害锛屽欢闀峰偓鍖栨晥鏋�锛屽悓鏅傛彁楂樺劜瀛樼┅(w臎n)瀹氭€�銆�

4. 琛ㄩ潰铏曠悊锛氬皪DMAP椤嗙矑閫茶琛ㄩ潰铏曠悊锛屽彲浠ユ敼鍠勫叾鍦ㄤ笉鍚屾憾鍔戜腑鐨勫垎鏁ｆ€у拰绌�(w臎n)瀹氭€�銆�

5. 鍙嶆噳(y墨ng)姊濅欢鍎�(y艒u)鍖栵細閫氶亷瑾�(di脿o)绡€(ji茅)鍙嶆噳(y墨ng)婧害銆佸鍔涘拰鏀媽閫熷害绛夊弮鏁�(sh霉)锛屽彲浠ュ厖鍒嗙櫦(f膩)鎻瓺MAP鐨勫偓鍖栨經鍔涳紝鐛插緱鍎�(y艒u)鐨勭敘(ch菐n)鍝佹€ц兘銆�

鍏€丏MAP鐨勭櫦(f膩)灞曟绋嬭垏鍦嬪収(n猫i)澶栫爺绌堕€插睍

6.1 鐧�(f膩)灞曟绋嬪洖椤�

DMAP鐨勭櫦(f膩)鐝�(xi脿n)鍙互杩芥函鍒�20涓栫磤(j矛)涓湡锛岀暥(d膩ng)鏅傜瀛�(xu茅)瀹跺€戝湪鐮旂┒闆滅挵(hu谩n)鍖栧悎鐗╃殑閬庣▼涓娆″悎鎴愪簡閫欑ó鍖栧悎鐗┿€傜劧鑰�锛屽叾鍦ㄨ仛姘ㄩ叝闋�(l菒ng)鍩熺殑鎳�(y墨ng)鐢ㄥ嵒鏄繎骞惧崄骞存墠閫愭几鐧�(f膩)灞曡捣渚嗙殑銆傛棭鏈熺殑鐮旂┒涓昏闆嗕腑鍦ㄥ叾浣滅偤鏈夋鍚堟垚瑭﹀姂鐨勬噳(y墨ng)鐢�锛岀洿鍒�1970骞翠唬鏈湡锛岄毃钁楄仛姘ㄩ叝宸ユキ(y猫)鐨勫揩閫熺櫦(f膩)灞曪紝鐮旂┒浜哄摗闁嬪闂�(gu膩n)娉―MAP鍦ㄨ仛姘ㄩ叝鍙嶆噳(y墨ng)涓殑鍌寲鎬ц兘銆�

閫插叆21涓栫磤(j矛)浠ヤ締锛孌MAP鍦ㄨ仛姘ㄩ叝瀵嗗皝鑶犱腑鐨勬噳(y墨ng)鐢ㄥ緱鍒颁簡杩呴€熺櫦(f膩)灞�銆傜壒鍒ユ槸鍦�2005骞翠互鍚庯紝闅ㄨ憲鐠�(hu谩n)淇濇硶瑕�(gu墨)鏃ョ泭鍤�(y谩n)鏍�锛屽偝绲�(t菕ng)閷鍌寲鍔戠殑浣跨敤鍙楀埌闄愬埗锛孌MAP鎲戝€熷叾鍎�(y艒u)鐣扮殑鍌寲鎬ц兘鍜岀挵(hu谩n)淇濈壒鎬э紝閫愭鍙栦唬閮ㄥ垎鍌崇当(t菕ng)鍌寲鍔�锛屾垚鐐鸿妤�(y猫)鐧�(f膩)灞曠殑鏂版柟鍚戙€傝繎骞翠締锛岄毃钁楃磵绫虫妧琛�(sh霉)鍜岃〃闈㈡敼鎬ф妧琛�(sh霉)鐨勯€叉锛孌MAP鐨勬噳(y墨ng)鐢ㄧ爺绌堕€插叆浜嗘柊鐨勭櫦(f膩)灞曢殠娈�銆�

6.2 鍦嬪収(n猫i)澶栫爺绌剁従(xi脿n)鐙€

鍦嬪鍦―MAP鐨勭爺绌舵柟闈㈣捣姝ヨ純鏃�锛岀編鍦嬪拰姝愭床鐨勭浉闂�(gu膩n)鐮旂┒姗熸(g貌u)鍦ㄥ熀绀�(ch菙)鐞嗚珫鍜屾噳(y墨ng)鐢ㄦ妧琛�(sh霉)鏂归潰閮藉彇寰椾簡椤憲鎴愭灉銆備互缇庡湅闄舵皬鍖栧(xu茅)鍏徃鐐轰唬琛ㄧ殑鍦嬮殯浼佹キ(y猫)锛岀巼鍏堥枊灞曚簡DMAP鍦ㄩ珮鎬ц兘鑱氭皑閰瘑灏佽啝涓殑鎳�(y墨ng)鐢ㄧ爺绌�锛屽苟鍙栧緱浜嗗闋呭皥鍒╂妧琛�(sh霉)銆傚痉鍦嬪反鏂か鍏徃鍓囪憲閲嶇爺绌禗MAP鐨勫姛鑳藉寲鏀规€у強鍏跺湪鐗圭ó鑱氭皑閰珨绯讳腑鐨勬噳(y墨ng)鐢�锛岄枊鐧�(f膩)鍑轰簡涓€绯诲垪楂樻€ц兘鐢�(ch菐n)鍝�銆�

鍦ㄥ湅鍏�(n猫i)锛屾竻鑿ぇ瀛�(xu茅)鍖栧伐绯�銆佷腑绉戦櫌鍖栧(xu茅)鎵€绛夌鐮旀妲�(g貌u)鍦―MAP鐨勫熀绀�(ch菙)鐮旂┒鏂归潰鍙栧緱浜嗛噸瑕侀€插睍銆傛禉姹熷ぇ瀛�(xu茅)鏉愭枡瀛�(xu茅)闄㈤嚌灏岲MAP鍦ㄦ繒姘ｅ浐鍖栬仛姘ㄩ叝瀵嗗皝鑶犱腑鐨勬噳(y墨ng)鐢ㄩ€茶浜嗙郴绲�(t菕ng)鐮旂┒锛屾彁鍑轰簡澶氱ó鏀规€ф柟妗�銆傝彲鍗楃悊宸ュぇ瀛�(xu茅)鍓囬噸榛炵爺绌禗MAP鍦ㄩ浕瀛愮礆鑱氭皑閰瘑灏佽啝涓殑鎳�(y墨ng)鐢紝闁嬬櫦(f膩)鍑哄叿鏈夎嚜涓荤煡璀樼敘(ch菐n)娆�(qu谩n)鐨勭敘(ch菐n)鍝�銆�

琛�3锛氬湅鍏�(n猫i)澶朌MAP鐮旂┒閫插睍灏嶆瘮

6.3 鏂版妧琛�(sh霉)绐佺牬

杩戝勾渚�锛孌MAP鐨勭爺绌跺彇寰椾簡鑻ュ共閲嶈绐佺牬銆傚湪鍌寲姗熷埗鏂归潰锛岀爺绌朵汉鍝″埄鐢ㄥ悓姝ヨ蓟灏勬妧琛�(sh霉)鍜屽師浣嶇磪澶栧厜璀滄妧琛�(sh霉)锛岄娆℃彮绀轰簡DMAP鍦ㄨ仛姘ㄩ叝鍙嶆噳(y墨ng)涓殑寰浣滅敤姗熺悊锛岀偤鍎�(y艒u)鍖栧叾鎳�(y墨ng)鐢ㄦ彁渚涗簡鐞嗚珫渚濇摎(j霉)銆傚湪鍔熻兘鍖栨敼鎬ф柟闈�锛岄€氶亷寮曞叆绱嶇背绮掑瓙鍜岃〃闈㈡椿鎬у姂锛屾垚鍔熼枊鐧�(f膩)鍑哄叿鏈夊畾鍚戝偓鍖栨€ц兘鐨勬柊鍨婦MAP琛嶇敓鐗�銆�

鐗瑰垾鏄湪缍犺壊鍚堟垚鎶€琛�(sh霉)鏂归潰锛岀爺绌朵汉鍝￠枊鐧�(f膩)鍑轰互鍙啀鐢熻硣婧愮偤鍘熸枡鐨凞MAP鍚堟垚璺窔锛岄’钁楅檷浣庝簡鐢熺敘(ch菐n)鎴愭湰鍜岀挵(hu谩n)澧冩薄鏌�銆傚悓鏅傦紝閫氶亷鏀归€茬敓鐢�(ch菐n)宸ヨ棟锛屽鐝�(xi脿n)浜咲MAP鐨勯€ｇ簩(x霉)鍖栫敓鐢�(ch菐n)锛岀敘(ch菐n)鍝佺磾搴﹀彲閬�(d谩)99.9%浠ヤ笂锛屾豢瓒抽珮绔噳(y墨ng)鐢ㄩ渶姹傘€�

灞曟湜鏈締锛岄毃钁楁柊鏉愭枡鎶€琛�(sh霉)鐨勪笉鏂烽€叉鍜屾噳(y墨ng)鐢ㄩ渶姹傜殑鎸佺簩(x霉)澧為暦锛孌MAP鐨勭爺绌跺拰鎳�(y墨ng)鐢ㄥ繀灏囪繋渚嗘洿鍔犲唬闂婄殑鐧�(f膩)灞曠┖闁撱€�

涓�銆丏MAP鐨勫墠鏅睍鏈涜垏鏈締鐧�(f膩)灞�

闅ㄨ憲绉戞妧鐨勪笉鏂烽€叉鍜屽競鍫撮渶姹傜殑璁婂寲锛孌MAP鍦ㄦ湭渚嗙殑鐧�(f膩)灞曚腑灞曠従(xi脿n)鍑哄唬闂婄殑鍓嶆櫙鍜屽法澶х殑娼涘姏銆傞鍏�锛屽湪鐠�(hu谩n)淇濇硶瑕�(gu墨)鏃ョ泭鍤�(y谩n)鏍肩殑鑳屾櫙涓嬶紝DMAP浣滅偤闈為噾灞湁姗熷偓鍖栧姂鐨勫劒(y艒u)鍕㈠皣寰楀埌閫蹭竴姝ュ嚫椤�銆傞爯(y霉)瑷堝湪鏈締鍗佸勾鍏�(n猫i)锛孌MAP鍦ㄨ仛姘ㄩ叝瀵嗗皝鑶犲競鍫寸殑鍗犳湁鐜囧皣鎻愬崌鑷�30%浠ヤ笂锛屾垚鐐轰富娴佸偓鍖栧姂涔嬩竴銆�

寰炴妧琛�(sh霉)鐧�(f膩)灞曡定鍕締鐪嬶紝DMAP鐨勫姛鑳藉寲鏀规€у拰绱嶇背鍖栧皣鏄噸瑕佺殑鐮旂┒鏂瑰悜銆傞€氶亷寮曞叆鏅鸿兘闊挎噳(y墨ng)鍩哄湗锛岄枊鐧�(f膩)鍑哄叿鏈夋韩搴�銆佹繒搴︾瓑鐠�(hu谩n)澧冨洜瀛愰熆鎳�(y墨ng)鐗规€х殑鏂板瀷DMAP琛嶇敓鐗�锛屽皣鐐鸿仛姘ㄩ叝瀵嗗皝鑶犲付渚嗘洿绮炬簴(zh菙n)鐨勬€ц兘瑾�(di脿o)鎺ц兘鍔涖€傚悓鏅�锛岄噰鐢ㄧ稜鑹插悎鎴愭妧琛�(sh霉)鐢熺敘(ch菐n)鐨勭敓鐗╁熀DMAP锛屾湁鏈涢€蹭竴姝ラ檷浣庣敓鐢�(ch菐n)鎴愭湰骞舵彁楂樼挵(hu谩n)澧冨弸濂芥€�銆�

鍦ㄦ噳(y墨ng)鐢ㄩ牁(l菒ng)鍩熸嫇灞曟柟闈紝DMAP灏囧湪鏂拌垐闋�(l菒ng)鍩熷睍鐝�(xi脿n)鏇村ぇ鐨勫児鍊�銆備緥濡傦紝鍦ㄨ埅绌鸿埅澶╅牁(l菒ng)鍩�锛岄嚌灏嶆サ绔挵(hu谩n)澧冩浠堕枊鐧�(f膩)鐨勯珮鎬ц兘鑱氭皑閰瘑灏佽啝锛屽皣渚濊炒DMAP瀵︾従(xi脿n)鏇寸簿纰虹殑鍙嶆噳(y墨ng)鎺у埗锛涘湪閱�(y墨)鐧傞牁(l菒ng)鍩�锛岀敤浜庣敓鐗╃浉瀹规€ф潗鏂欑殑鑱氭皑閰珨绯�锛屽皣鍊熷姪DMAP瀵︾従(xi脿n)鏇存韩鍜岀殑鍙嶆噳(y墨ng)姊濅欢鍜屾洿楂樼殑鐢�(ch菐n)鍝佺磾鍑堝害銆�

姝ゅ锛岄毃钁楁櫤鑳藉埗閫犲拰宸ユキ(y猫)4.0鐨勬帹閫�锛孌MAP鍦ㄨ嚜鍕曞寲鐢熺敘(ch菐n)鍜屾櫤鑳界洠(ji膩n)鎺т腑鐨勬噳(y墨ng)鐢ㄤ篃灏囧緱鍒板姞寮枫€傞€氶亷鑸囧湪绶氱洠(ji膩n)娓郴绲�(t菕ng)鐩哥祼(ji茅)鍚�锛屽鐝�(xi脿n)DMAP鐢ㄩ噺鐨勭簿纰烘帶鍒跺拰鍙嶆噳(y墨ng)閬庣▼鐨勫鏅傚劒(y艒u)鍖栵紝灏囬€蹭竴姝ユ彁鍗囩敓鐢�(ch菐n)鏁堢巼鍜岀敘(ch菐n)鍝佽唱(zh矛)閲�銆傚彲浠ラ爯(y霉)瑕�锛孌MAP灏囧湪鏈締鐨勮仛姘ㄩ叝鎶€琛�(sh霉)鐧�(f膩)灞曚腑鎵紨鏇村姞閲嶈鐨勮鑹�锛屾帹鍕曡妤�(y猫)鍚戞洿楂樺堡娆￠倎閫层€�

鎿村睍闁辫畝:https://www.bdmaee.net/quick-drying-tin-tributyltin-oxide-hardening-catalyst/

鎿村睍闁辫畝:https://www.newtopchem.com/archives/212

鎿村睍闁辫畝:https://www.newtopchem.com/archives/40394

鎿村睍闁辫畝:https://www.cyclohexylamine.net/dabco-amine-catalyst-amine-catalyst/

鎿村睍闁辫畝:https://www.morpholine.org/category/morpholine/page/5391/

鎿村睍闁辫畝:https://www.newtopchem.com/archives/category/products/page/34

鎿村睍闁辫畝:https://www.morpholine.org/bismuth-octoate/

鎿村睍闁辫畝:https://www.newtopchem.com/archives/1837

鎿村睍闁辫畝:https://www.bdmaee.net/nt-cat-t96-catalyst-cas103-83-3-newtopchem/

鎿村睍闁辫畝:https://www.newtopchem.com/archives/44867