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缍滃悎瑭曚及

妤电姘ｅ€欐浠朵笅鐨勭┅(w臎n)瀹氭€ц⿻浼板苟闈炲柈涓€缍害鐨勫晱椤�锛岃€屾槸闇€瑕佺稖鍚堣€冩叜婧害銆佹繒搴︿互鍙婂叾浠栫挵(hu谩n)澧冨洜绱犵殑鐩镐簰浣滅敤銆備緥濡傦紝鍦ㄩ珮婧珮婵曠殑鐔卞付鍦板崁(q奴)锛孴MBPA涓嶅儏瑕佹姷鎶楅珮婧付渚嗙殑鍒嗚В棰�(f膿ng)闅紝閭勮鎳�(y墨ng)灏嶆繒搴﹀紩璧风殑鍚告疆鍟忛锛涜€屽湪浣庢韩楂樻繒鐨勬サ鍦板湴鍗€(q奴)锛屽墖闇€瑕佸吋椤т綆婧皫(d菐o)鑷寸殑娴佸嫊鎬т笅闄嶅拰婵曞害寮曠櫦(f膩)鐨勮〃闈㈣畩鍖�銆�

閫氶亷浠ヤ笂鍒嗘瀽锛屾垜鍊戝彲浠ョ湅鍒�锛孴MBPA鍦ㄦサ绔埃鍊欐浠朵笅鐨勭┅(w臎n)瀹氭€у苟闈炵禃灏嶏紝鑰屾槸渚濊炒浜庡叿楂旂殑鐠�(hu谩n)澧冨弮鏁�(sh霉)鍜屼娇鐢ㄥ牬鏅�銆傛帴涓嬩締锛屾垜鍊戝皣閫蹭竴姝ユ帰瑷嶵MBPA鐨勫垎瀛愮祼(ji茅)妲�(g貌u)濡備綍姹哄畾鍏跺湪閫欎簺姊濅欢涓嬬殑琛ㄧ従(xi脿n)銆�

TMBPA鐨勫垎瀛愮祼(ji茅)妲�(g貌u)鑸囩┅(w臎n)瀹氭€ф鍒�

TMBPA涔嬫墍浠ヨ兘澶犲湪妤电姘ｅ€欐浠朵笅琛ㄧ従(xi脿n)鍑鸿壊锛岃垏鍏剁崹鐗圭殑鍒嗗瓙绲�(ji茅)妲�(g貌u)瀵嗕笉鍙垎銆傝畵鎴戝€戜竴璧疯蛋閫插井瑙€涓栫晫锛屾帰绱㈤€欏€嬧€滃寲瀛�(xu茅)鍫″鈥濈殑鍏�(n猫i)閮ㄦ(g貌u)閫�銆�

鍒嗗瓙绲�(ji茅)妲�(g貌u)姒傝

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绌�(w臎n)瀹氭€ф鍒惰В鏋�

TMBPA鐨勭┅(w臎n)瀹氭€т富瑕佷締婧愪簬浠ヤ笅骞惧€嬫柟闈細

1. 姘嵉鐨勪綔鐢�

浜炴皑鍩猴紙-NH-锛夌殑瀛樺湪浣垮緱TMBPA鍒嗗瓙涔嬮枔鑳藉褰㈡垚寮峰ぇ鐨勬矮閸电恫(w菐ng)绲�(lu貌)銆傞€欑ó缍�(w菐ng)绲�(lu貌)灏卞儚涓€寮电劇褰㈢殑缍�(w菐ng)锛屽皣鍒嗗瓙鐗㈢墷鍦板浐瀹氬湪涓€璧凤紝闃叉瀹冨€戝湪楂樻韩鎴栭珮婵曟浠朵笅杓曟槗鍒嗛洟銆傛濡傝湗铔涚恫(w菐ng)鑳藉鎹曟崏椋涜煵涓€妯�锛屾矮閸电恫(w菐ng)绲�(lu貌)涔熻兘鏈夋晥鎹曠嵅澶栫晫鐨勮兘閲忔矕鎿娿€�

2. 鐑峰熀鐨勪繚璀锋晥鎳�(y墨ng)

闀烽張鐑峰熀璧峰埌浜嗗睆钄戒綔鐢�锛屼繚璀锋牳蹇冪祼(ji茅)妲�(g貌u)鍏嶅彈澶栫晫鐠�(hu谩n)澧冪殑褰遍熆銆傞€欑ó淇濊椤炰技浜庣郸鎴垮瓙鍔犺闅旂啽灞�锛屽嵆浣垮閮ㄦ韩搴﹀妵鐑堟尝鍕�锛屽収(n猫i)閮ㄧ挵(hu谩n)澧冧緷鐒跺彲浠ヤ繚鎸佺┅(w臎n)瀹�銆�

3. 灏嶇ū鎬у劒(y艒u)鍕�

灏嶇ū鐨勫垎瀛愮祼(ji茅)妲�(g貌u)浣垮緱TMBPA鍦ㄥ彈鍔涙檪鑳藉鍧囧嫽鍒嗗竷澹撳姏锛岄伩鍏嶅眬閮ㄦ噳(y墨ng)鍔涢亷澶у皫(d菐o)鑷寸殑鐮磋銆傞€欑ó鐗规€ч浼间簬姹借粖杓儙鐨勮ō(sh猫)瑷�锛岄€氶亷灏嶇ū鍒嗗竷杓夎嵎渚嗗欢闀蜂娇鐢ㄥ＝鍛�銆�

瀵﹂椹楄瓑

鐐轰簡閫蹭竴姝ラ璀塗MBPA鐨勫垎瀛愮祼(ji茅)妲�(g貌u)鑸囧叾绌�(w臎n)瀹氭€т箣闁撶殑闂�(gu膩n)绯�锛岀爺绌朵汉鍝￠€茶浜嗗闋呭椹�銆備緥濡�锛屽湪妯℃摤楂樻韩楂樻繒鐠�(hu谩n)澧冪殑瀵﹂涓�锛屼粬鍊戠櫦(f膩)鐝�(xi脿n)TMBPA鐨勫垎瀛愮祼(ji茅)妲�(g貌u)鍦ㄧ稉(j墨ng)姝烽暦閬旀暩(sh霉)鍛ㄧ殑娓│鍚庝粛鐒朵繚鎸佸畬鏁�銆傞€欏厖鍒嗚瓑鏄庝簡鍏跺垎瀛愯ō(sh猫)瑷堢殑鍎�(y艒u)瓒婃€с€�

閫氶亷閫欎簺瀵﹂鏁�(sh霉)鎿�(j霉)锛屾垜鍊戝彲浠ユ洿鍔犵洿瑙€鍦版劅鍙楀埌TMBPA鍒嗗瓙绲�(ji茅)妲�(g貌u)鐨勭簿濡欎箣铏�銆傚畠涓嶅儏鏄竴绋寲瀛�(xu茅)鐗╄唱(zh矛)锛屾洿鏄竴浠惰棟琛�(sh霉)鍝�锛屽畬缇庡湴骞宠　浜嗗姛鑳借垏缇庡(xu茅)銆�

鍦嬪収(n猫i)澶栨枃鐛荤稖杩帮細TMBPA鍦ㄦサ绔埃鍊欐浠朵笅鐨勭爺绌堕€插睍

闂�(gu膩n)浜嶵MBPA鍦ㄦサ绔埃鍊欐浠朵笅鐨勭┅(w臎n)瀹氭€х爺绌�锛屽湅鍏�(n猫i)澶栧(xu茅)鑰呭凡缍�(j墨ng)鍙栧緱浜嗚ū澶氶噸瑕佹垚鏋�銆傞€欎簺鐮旂┒鎴愭灉涓嶅儏鍔犳繁浜嗘垜鍊戝皪TMBPA鐨勭悊瑙ｏ紝涔熺偤鍏跺鐢ㄥ寲鎻愪緵浜嗙悊璜栨敮鎸�銆�

鍦嬪収(n猫i)鐮旂┒鐝�(xi脿n)鐙€

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涓昏鐧�(f膩)鐝�(xi脿n)

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鍦嬪鐮旂┒鍕曟厠(t脿i)

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鍓�(chu脿ng)鏂版妧琛�(sh霉)

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缍滃悎姣旇純

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閫氶亷閫欎簺鏂囩嵒鐨勭附绲�(ji茅)锛屾垜鍊戝彲浠ョ湅鍒�锛孴MBPA鐨勭爺绌跺凡缍�(j墨ng)閫插叆浜嗕竴鍊嬪叏鏂扮殑闅庢銆傛湭渚嗭紝闅ㄨ憲鎶€琛�(sh霉)鐨勯€叉鍜岄渶姹傜殑澧為暦锛孴MBPA蹇呭皣鍦ㄦ洿澶氶牁(l菒ng)鍩熷睍鐝�(xi脿n)鍏剁崹鐗归瓍鍔涖€�

绲�(ji茅)璜栬垏灞曟湜锛歍MBPA鐨勬湭渚嗕箣璺�

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鐣�(d膩ng)鍓嶆垚灏�

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